Release time：2023-11-29 Click:
It's reported that Calcium L-5-methyltetrahydrofolate was not acutely toxic to rats after a singleoral dose ( LDSO > 2000 mg / kg bw ) : no gross changes in organs were observed atand all animals gained weight and survived until end of the 15-dayobservation period . In a short-term study of toxicity in male and female Wistar ratsgiven calcium L-5-methyltetrahydrofolate orally for 13 weeks , no adverse effectswere seen. Studies in humans indicate that L-5-methyltetrahydrofolic acid is the only form of folate normally taken up by cells and appearing in plasma , and that cellularuptake is mediated by a reduced folate carrier and folate receptors , which are integralplasma membrane proteins At exposure to folate of > 200-300 ug / day per persthe metabolicle human intestinal mucosa for folic acid beans to beexceeded , resulting in small amounts of unaltered folic acid in circulating blood. [1]
L-5-Methyltetrahydrofolate calcium would be a great folate source to the needs of those seeking the highest-quality folate available as well as those with MTHFR gene mutations.
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Reference :
[1] CALCIUM L-5-METHYLTETRAH YDROFOLATE First draft prepared by L.G. Valerio , Jrl , C . Leclerca and J . SchlatterCenter for Food Safety and Applied Nutrition , US Food and DrugAdministration , College Park , Maryland , USA2national Research Institute for Food and Nutrition , Rome , Italy ; andSwiss Federal Office of Public Health , Zurich . Switzerland