OCT: The 3^rd generation anti-dandruff

CAS.68890-66-4

Leading Chem is the Largest supplier for OCT worldwide.

- What’s OCT

Chemical name: Piroctone Olamine（C14H23NO2.C2H7NO）

Molecular weight : 298.42

Appearance: White to Light Yellow Crystal Powder

Purity (HPLC, AR): 99.0%min.

Recommend dosage:

Flushing Shampoo- ≤1.0%

No-clean shampoo- ≤0.5%

-Did you know, the common ingredient for anti-dandruff?

1st genertaion

Sulfur, salicylic acid, selenium disulfide

Irritating, little used now

2nd genertaion

Zinc pyrithione (ZPT) & Clomiprazole (CLM)

ZPT was listed as CMR* and has been forbidden from 1,March,2022

3rd genertaion

Piroctone Olamine(OCT)

Mild, Safe and powerful

-How about the clinical effect on dandruff of OCT?

Time

OCT

ZPT

After 42 days

(compared to control group)

decrease 54.5%

Note: There is a significant anti dandruff effect in 14 days

After 42 days (Compared to ZPT)

decrease 81.7%

decrease 68.6%

-How about the safety?

lAcute toxicity

ZPT	LD50 170mg/kg
CLM	LD50 400mg/kg
OCT	LD50 8100mg/kg （The most safe)

lOther toxicity

Chronic toxicity	No chronic toxicity. The Long term oral and skin application tests are safe.
Allergenicity	NO
Embryotoxicity and teratogenicity	NO
Gene mutagenicity	NO

*CMR: carcinogenic, mutagenic or toxic for reproduction

Reference:[1] Eberhard futterer,PHD hoecbst Aktiengesellscbaft.Evaluation of efficacy of antidandruff agents[J].Journal of the society of cosmetic chemists,1981,32: 327-338

[2]https://www.doc88.com/p-14259584343223.html

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