Glutathione
Reduced form& S-Acetyl L-Glutathione & Oxidized form
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Glutathione (GSH) is an antioxidant involved in many metabolic and cell cycle-associated cell functions. Increasing its plasma levels may have beneficial systemic effects and may be of therapeutic relevance. GSH intake via the oral route does not successfully enhance GSH in plasma, due to its metabolization in the gut. Hence, many attempts have been made to develop GSH derivatives able to easily cross the cell membranes and to enhance its oral bioavailability.
-We are supplying three kinds of glutathione.
L-Glutathione (GSH)
S-Acetyl L-Glutathione (SAG)
Oxidized Glutathione (GSSG)
SAG&GSSG are GHS derivatives.
-What’s GSH?
Glutathione (GSH) is a tripeptide (γ-L-glutamyl-L-cysteinylglycine) characterized by an atypical peptide bond
linking the nitrogen of cysteine to the carboxyl in γ-glutamic acid. GSH is found ubiquitously in nature, both in animals and in plants and microorganisms. Its ubiquitous distribution virtually in all kingdoms of life suggests that GSH plays a fundamental role in the cell and may indicate a conserved role in evolution.
CAS. 70-18-8
C10H17N3O6S
Molecular weight: 307.3
-What’s SAG?
CAS: 3054-47-5
S-Acetylglutathione (SAG) is a GSH precursor, it is more stable than GSH itself in plasma and is taken up directly by cells and later converted to GSH.(Figure 1)
SAG VS GSH
ØMore stable and easy to be absorbed.
Ø No unpleasant sulfhydryl taste, which can quickly increase the level of reduced glutathione in the cell without increasing energy consumption.
Ø It is more effective in supplementing the cell level of glutathione that is lacking due to virus infection.
-What’s GSSG?
It is formed by two oxidized reduced glutathione. Bonded by disulfide (SS) bonds, oxidized glutathione has been shown to be more stable in water and high temperature .
CAS. 27025-41-8
C20H32N6O12S2
Molecular weight: 612.6
Advantages of GSSG
Ø Aqueous stable glutathione
Ø Very stable against light and heat
Ø Generally regulates melanin production within the living body as reduced type of glutathione
Ø Easily be converted into glutathione reduced by redox enzyme in human skin
ØHas a significant effect on skin whitening of human skin
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