OCT: The 3rd generation anti-dandruff
CAS.68890-66-4
Leading Chem is the Largest supplier for OCT worldwide.
- What’s OCT
Chemical name: Piroctone Olamine（C14H23NO2.C2H7NO）
Molecular weight : 298.42
Appearance: White to Light Yellow Crystal Powder
Purity (HPLC, AR): 99.0%min.
Recommend dosage:
Flushing Shampoo- ≤1.0%
No-clean shampoo- ≤0.5%
-Did you know, the common ingredient for anti-dandruff?
1st genertaion
Sulfur, salicylic acid, selenium disulfide
Irritating, little used now
2nd genertaion
Zinc pyrithione (ZPT) & Clomiprazole (CLM)
ZPT was listed as CMR* and has been forbidden from 1,March,2022
3rd genertaion
Piroctone Olamine(OCT)
Mild, Safe and powerful
-How about the clinical effect on dandruff of OCT?
Time | OCT | ZPT |
After 42 days (compared to control group) | decrease 54.5% Note: There is a significant anti dandruff effect in 14 days | / |
After 42 days (Compared to ZPT) | decrease 81.7% | decrease 68.6% |
-How about the safety?
lAcute toxicity
ZPT | LD50 170mg/kg |
CLM | LD50 400mg/kg |
OCT | LD50 8100mg/kg （The most safe) |
lOther toxicity
Chronic toxicity | No chronic toxicity. The Long term oral and skin application tests are safe. |
Allergenicity | NO |
Embryotoxicity and teratogenicity | NO |
Gene mutagenicity | NO |
*CMR: carcinogenic, mutagenic or toxic for reproduction
Reference:[1] Eberhard futterer,PHD hoecbst Aktiengesellscbaft.Evaluation of efficacy of antidandruff agents[J].Journal of the society of cosmetic chemists,1981,32: 327-338
[2]https://www.doc88.com/p-14259584343223.html
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